What Are Peptide Sequences?
A peptide sequence is the specific order of amino acids in a peptide chain, written from the N-terminus (amino end) to the C-terminus (carboxyl end). This sequence is the fundamental identifier of any peptide and determines its biological activity, structure, and properties.
Amino Acid Building Blocks
Peptides are built from 20 standard amino acids, each with a unique side chain that determines its chemical properties. Amino acids are represented by three-letter codes (e.g., Gly, Ala, Leu) or single-letter codes (G, A, L). The sequence of these amino acids — not just which ones are present — determines the peptide’s function.
Reading Peptide Sequences
By convention, peptide sequences are written left to right from N-terminus to C-terminus. For example, BPC-157‘s sequence is a 15-amino acid chain: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val. This specific arrangement gives BPC-157 its unique tissue-protective properties.
How Sequence Determines Function
Even small changes in amino acid sequence can dramatically alter a peptide’s activity. Substituting a single amino acid can increase or decrease receptor binding affinity, alter enzymatic stability, change folding patterns, or modify pharmacokinetic properties.
Sequence Verification
Mass spectrometry confirms that a synthesized peptide matches its intended sequence by verifying molecular weight. HPLC confirms purity. Together, these tests — included in every Proxiva Labs COA — ensure you’re researching the correct compound.
Related Articles: Peptide Folding Guide | How Are Peptides Made? | What is Peptide Purity?
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