Selank: Complete Research Guide
Selank is a synthetic peptide derived from tuftsin, an endogenous immunomodulatory peptide. Developed at the Institute of Molecular Genetics (Russian Academy of Sciences), Selank is studied for its anxiolytic, nootropic, and immunomodulatory properties.
Structure & Mechanism
Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) is tuftsin with a Pro-Gly-Pro tail that enhances metabolic stability. It influences: GABA-A receptor expression, serotonin and dopamine metabolism, BDNF and NGF production, enkephalin system modulation, and IL-6 and interferon expression.
Research Applications
Anxiolytic research: Selank demonstrates anxiety-reducing effects comparable to benzodiazepines in animal models without sedation or dependence. Nootropic research: Memory enhancement, learning facilitation, and cognitive flexibility improvement. Immunomodulatory research: Derived from tuftsin, Selank retains immune-enhancing properties including phagocyte activation and Th1/Th2 balance.
Administration
Selank is typically researched via intranasal administration, providing direct CNS access through olfactory pathways. This route achieves 10-30% bioavailability while bypassing first-pass metabolism.
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