What Is BPC-157?
BPC-157 (Body Protection Compound-157) is a synthetic pentadecapeptide — a chain of 15 amino acids — derived from a naturally occurring protein found in human gastric juice. Its amino acid sequence is GEPPPGKPADDAGLV, with a molecular weight of approximately 1,419.53 g/mol.
First isolated and characterized in the early 1990s, BPC-157 has become one of the most extensively studied peptides in preclinical research. It has been the subject of hundreds of published studies investigating its potential role in tissue repair, wound healing, and cytoprotective mechanisms.
BPC-157 is classified as a research peptide and is not approved by the FDA for any clinical application. All information presented here is for educational purposes related to laboratory research.
Chemical Profile
- Full Name: Body Protection Compound-157
- Sequence: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val
- Molecular Formula: C??H??N??O??
- Molecular Weight: 1,419.53 g/mol
- CAS Number: 137525-51-0
- Purity: ?99% (HPLC verified) at Proxiva Labs
- Storage: Lyophilized form stable at -20°C for long-term; 2-8°C short-term
Research Background
BPC-157 research began at the University of Zagreb in Croatia, where Dr. Predrag Sikiric and colleagues first characterized the compound. Since then, over 100 peer-reviewed studies have been published, predominantly using rodent models.
Key areas of preclinical investigation include:
Tissue Repair and Wound Healing
Multiple studies have investigated BPC-157’s effects on various tissue types in animal models. Research has examined its interaction with tendon, ligament, muscle, bone, and skin tissue in controlled laboratory settings. Studies in rats have shown accelerated healing of surgically transected tendons, with researchers observing increased collagen organization at the repair site.
Gastrointestinal Research
As a compound derived from gastric juice proteins, BPC-157 has been studied extensively in GI-related research models. Studies have examined its effects on experimentally-induced stomach ulcers, inflammatory bowel conditions, and intestinal anastomosis healing in rodents. The compound’s stability in gastric acid makes it unique among peptides, as most peptides degrade rapidly in the acidic stomach environment.
Nitric Oxide System
Research has shown that BPC-157 interacts with the nitric oxide (NO) system. Studies suggest it may modulate NO synthase pathways, which play roles in vasodilation, inflammation, and cellular signaling. This NO system interaction is thought to be one mechanism underlying the compound’s observed effects in various research models.
Growth Factor Pathways
Preclinical studies have investigated BPC-157’s interaction with several growth factor pathways, including VEGF (vascular endothelial growth factor), EGF (epidermal growth factor), and FAK-paxillin signaling. These pathways are involved in angiogenesis, cell proliferation, and tissue remodeling.
Research Dosing in Published Studies
In the published literature, BPC-157 has been studied across a range of doses in animal models:
- Typical rodent doses: 10 mcg/kg to 10 mg/kg body weight
- Routes of administration studied: Intraperitoneal (IP), subcutaneous, intragastric, topical, intramuscular
- Duration: Varies widely from single-dose studies to 14+ day protocols
It is important to note that rodent dosing does not directly translate to other species. Allometric scaling and pharmacokinetic differences must be considered in any translational research context.
Available Forms
BPC-157 is commercially available for research purposes in several forms:
- Lyophilized powder — The most common form. Reconstitute with bacteriostatic water before use. Available in 5mg and 10mg vials at Proxiva Labs
- Oral tablets/capsules — BPC-157’s gastric acid stability makes oral administration viable in research. BPC Tablets available here
For reconstitution instructions, see our complete reconstitution guide.
Reconstitution and Handling
BPC-157 is relatively straightforward to reconstitute:
- Allow the vial to reach room temperature
- Wipe both vial stoppers with alcohol swabs
- Add bacteriostatic water slowly along the vial wall (1-2mL for 5mg; 2mL for 10mg)
- Gently swirl — do not shake
- Store reconstituted solution at 2-8°C (36-46°F)
- Use within 4 weeks of reconstitution
Storage Guidelines
- Lyophilized (unreconstituted): Store at -20°C for maximum stability. Stable at 2-8°C for several months. Room temperature acceptable for short transit periods.
- Reconstituted solution: Refrigerate at 2-8°C. Use within 4-6 weeks when reconstituted with BAC water.
- Avoid: Repeated freeze-thaw cycles, direct sunlight, temperatures above 25°C for extended periods.
Quality and Purity Considerations
When sourcing BPC-157 for research, quality verification is essential. Look for:
- Third-party HPLC testing — High-performance liquid chromatography confirms peptide identity and purity
- Mass spectrometry verification — Confirms correct molecular weight
- Certificate of Analysis (COA) — Should be available for every batch
- Purity ?99% — Research-grade standard
All BPC-157 sold by Proxiva Labs meets these standards. View our Certificates of Analysis.
Published Research References
Selected peer-reviewed publications for further reading:
- Sikiric P, et al. “Stable gastric pentadecapeptide BPC 157: novel therapy in gastrointestinal tract.” Current Pharmaceutical Design. 2018.
- Chang CH, et al. “BPC 157 Enhances the Growth Hormone Receptor Expression in Tendon Fibroblasts.” Molecules. 2020.
- Seiwerth S, et al. “BPC 157’s Effect on Healing.” Journal of Physiology-Paris. 2014.
- Vukojevic J, et al. “Pentadecapeptide BPC 157 and the central nervous system.” Neural Regeneration Research. 2022.
Shop BPC-157
Proxiva Labs offers research-grade BPC-157 manufactured in the USA with 99.99% purity verified by independent HPLC testing. Every vial ships with a Certificate of Analysis.
Buy BPC-157 5mg & 10mg | Buy BPC Oral Tablets | Shop All Peptides
Disclaimer: BPC-157 is sold for laboratory and research use only. Not for human consumption. Not evaluated by the FDA.